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The double mutant pcs1pcs2 impaired in phytochelatin synthesis and the catabolism of glutathione conjugates 61,62 showed also a WT-like phenotype when exposed to AITC

and disease/tissue injury processes, such as those involved in atherogenesis, drug toxicity, and ischemia-reperfusion injury

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A comprehensive understanding of the molecular mechanisms underlying glutamine metabolism and its impact on both cancer cells and immune cells holds great promise in elucidating immune evasion mechanisms and facilitating the development of effective anti-cancer treatment strategies

Once activated, these receptors trigger a biochemical process that increases the production of eumelanin , the darker pigment responsible for skin coloration and natural UV protection