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Evaluation of the OPLS-DA model showed that the model group had R2 = 0.928 and Q2 = 0.264 compared with the control group (Figure 5G)

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Editorial: Chronobiology in cardiometabolic health and disease

Conversely, overfeeding increases intra-portal insulin levels that enhances hepatic GH sensitivity to a degree where relatively low GH secretion is sufficient to maintain ambient hepatic IGF-I synthesis and secretion, and normal circulating IGF-I levels ( Figure 1 This review summarizes how changes in hepatic exposure to intra-portal insulin in health and disease states modulates the GH/IGF-I axis

Sizmann D, Boeck C, Boelter J, Fischer D, Miethke M, Nicolaus S, et al