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Yes, some individuals experience mild abdominal cramping, bloating, or discomfort when taking vitamin B12 supplements, particularly on an empty stomach or with higher-dose formulations

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Exocrine pancreatic insufficiency (EPI) prevents animals from being able digest and absorb the nutrients from food, due to lack of digestive enzymes in the pancreas

Vitamin B 12 is needed to prevent anemia, since making porphyrin and heme in mitochondria for producing hemoglobin in red blood cells depends on succinyl-CoA made by vitamin B 12

Anesth Prog 38 Berlin R, Berlin H, Brante G, Pilbrant (1978) Vitamin B12 body stores during oral and parenteral treatment of pernicious anaemia