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Additionally, the overexpression of SIRT2 increases the deacetylation level of FoxO1 to inhibit autophagy in HK-2 cells treated with LPS and increases the production of pro-inflammatory factors, thereby aggravating CLP-induced SAKI (Yu et al., 2025)

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It's important to distinguish mild nutritional ketosis (generally benign) from diabetic ketoacidosis (a medical emergency), which is rare with GLP-1 receptor agonists alone but can occur if insulin doses are reduced too quickly

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