Unsuppressed water acquisitions were acquired from each voxel to provide a reference for absolute quantification and corrected for voxel CSF, which was greater in established patients but unaffected by diagnosis (Supplementary Figure 3.1 and Table 3.1)
Second, even taken at face value, an assay-specific potency ratio is not a measure of whole-organism effect: it does not mean Dihexa is millions of times more effective in a living brain, where absorption, distribution, and signaling context all differ
That search leads many to peptides
Epidemiological studies have linked an increased risk of autoimmune thyroiditis, Graves disease and goitre to low selenium status
The practical difference is who is in the driver's seat
Equally important is expanding investigation into alternative AMPK activation mechanisms, such as the PEN2-dependent lysosomal pathway, which may offer safer therapeutic avenues for patients at risk of mitochondrial dysfunction or lactic acidosis
