doi: 10.2337/dc09-0207
Hypothalamic Lipid Metabolism and Energy Homeostasis Hypothalamic Fatty Acid Metabolism Within the central nervous system the metabolism of fatty acids is primarily for the purposes of membrane function and the central regulation of energy metabolism
This means the appetite-suppressing effect of GLP-1, the fat-mobilizing effect of glucagon, and the insulin-enhancing effect of GIP all work together
CrossRef Impact of Fatty Liver Index on Cardiovascular Disease and Mortality across Alcohol Consumption Levels in Young Adults Byung-Hun Han, Joonyub Lee, Hun-Sung Kim, Jae-Hyoung Cho, Kyungdo Han, Seung-Hwan Lee Endocrinology and Metabolism.2026;[Epub] CrossRef Single-Cell Immune Atlases to Map Small Extracellular Vesicle Cargo in TuberculosisDiabetes Comorbidity: A Narrative Review and Conceptual Roadmap Ramona Cioboata, Silviu Gabriel Vlasceanu, Denisa Maria Mitroi, Anca Lelia Riza, Mara Amalia Balteanu, Oana Maria Catana, Mihai Olteanu International Journal of Molecular Sciences.2026
The ultimate pathways whereby these molecular changes may translate into changes in body weight and metabolic (dys)function are yet to be fully disclosed, but alterations in the hypothalamic proteome involved in inflammatory and apoptotic processes, as well as in autophagy and vesicular trafficking, may play a role
Weight regain
