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Basal lipolysis has been reported to be decreased in aFABP/ALBP/aP2-null mice compared with wild-type littermates (22, 49), and stimulated lipolysis in adipocytes isolated from these mice has also been shown to be attenuated (22, 110)

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While this effect appears to be related to the magnitude and rapidity of glucose lowering rather than a direct effect of the medication itself, patients with a history of diabetic retinopathy should undergo careful ophthalmologic evaluation before and during treatment, and the potential risks should be weighed against the expected benefits of improved glycemic control

A clinician wants a quick check of doubling time before a telehealth follow-up

Nat Rev Dis Primers 6