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Supplementary Figure 11 Activation of cGMP signaling in IPN does not alter nicotine intake

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Cen, K., et al

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Studies have demonstrated cerebral insulin resistance in AD patients using ex vivo insulin stimulation and measurement of this ratio in brain tissue ( Consequently, impaired insulin sensitivity reduces PI3K-Akt activation and downstream phosphorylation of proteins essential for neuronal survival, such as glycogen synthase kinase-3 (GSK3)