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No clinically relevant changes were observed for laboratory parameters or physical examination

Administration can occur simultaneously or separately based on convenience

No claims are made regarding safety, efficacy, or therapeutic application outside laboratory research

45.) Available from: Accessed 09.06.2025 Outterson K, Gopinathan U, Clift C, So AD, Morel CM, Rttingen J-A

In diet-induced obesity (DIO) models, NNMT loss-of-function and selective small-molecule inhibitors reduce white adipose mass and improve metabolic parameters without overt toxicity, positioning NNMT as a tractable target for metabolic-disease research [24]