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When estrogen levels drop, as they do in menopause, the resulting decrease in serotonin receptor expression and activity may contribute to the onset of mood disturbances, including depression and anxiety [40]

or extended-release metformin with evening meals at doses of 1000 or 2000 mg for 12 weeks

Guekht, Alla B., et al

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Exaggerated neutrophil extracellular trap formation further amplifies vascular inflammation and increases the risk of thrombosis in diabetic patients