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In one of these studies, the addition of 100 mg/kg/day of green tea extract to doxorubicin treatment normalized blood pressure and restored normal electrocardiogram results in the test animals, compared with those treated with doxorubicin alone (Patil 2011)

Notably, data suggests a cumulative effect following repeated exposure of the compound

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The stepped-care model offers a practical framework for treatment personalization, enabling clinicians to escalate interventions based on individual response patterns rather than adhering to arbitrary timelines

Piperine has been shown to have anti-inflammatory and anti-arthritic properties as well

doi: 10.7150/ijbs.94548 19 KosticADXavierRJGeversD