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The authors of the study hypothesize the rapid correction of blood sugar that tirzepatide causes leads to swelling in the optic nerve and NAION

Moreover, stable isotope-resolved metabolomics using [U-13C6] glucose showed that TZP blocked the conversion of glucose to TCA intermediates, such as citrate and malate, illustrating dual inhibition of glycolysis and oxidative metabolism

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While both medications contain the same active ingredient (tirzepatide), they are approved for different therapeutic indications and may have different dosing regimens

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