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Trial protocols are designed to test a drug safely, not to serve as dosing instructions for the public

Without a genuine training and nutrition stimulus there is little for the signal to act on

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However, at advanced stages of MASLD, this mitochondrial flexibility diminishes, leading to oxidative stress, inflammation, and release of mitochondrial damage-associated molecular patterns (mito-DAMPs), with mitochondrial DNA (mtDNA) fragments being one of their major components [66]

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