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[29] It has also been linked to optic nerve atrophy and neuritis

Acetoacetate can also be activated in the cytosol by the cytosolic enzyme, acetoacetyl-CoA synthetase (AACS)

Naltrexone, approved in 1984, introduced a non-opioid antagonist that blocked the effects of opioids but required full detoxification before initiation, limiting its early use

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The mechanism of protection after cerebral ischemic events is not very clear