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Mills, D

Notably, about 55% of commercial employers currently cover GLP-1s for obesity, but 15% of those have dropped coverage due to unsustainable costs. The proliferation of oral GLP-1s is expected to further increase pressure from employees to provide coverage, she added

Agonist medications mimic natural hormones, activating the same receptors

As a side note, it may be of interest that while the hunger hormone ghrelin appears to counteract (or rather override) the effects of GLP-1 on satiety, the commonly used anti-diabetic drug metformin appears to increase expression of GLP-1 receptors and enhance GLP-1 secretion and sensitivity in both rodents and humans

Many women will never need GLP-1s

Long-Term Maintenance After Weight Loss Reaching goal weight marks a transition rather than an endpoint