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B12 is filtered by the glomerulus

Individuals willing to commit to consistent 2+ month use with realistic expectations about gradual tissue repair processes rather than expecting immediate dramatic results

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[1] [8] Oral vs Injectable B12: Dosage Differences The route of B12 administration significantly affects the required dosage due to differences in bioavailability and absorption mechanisms

10.1007/s00441-019-03016-8 42 HendriksT.MastboomW

The general mechanism of CQD-facilitated targeted drug delivery is illustrated in Figure 5