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The pharmacological mechanism of tirzepatide involves simultaneous activation of both GIP and GLP-1 receptors, which are naturally occurring incretin hormones involved in glucose homeostasis and appetite regulation

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16 Before these newer DM medications were available, the commonly utilized PPG-lowering options were metformin, sulfonylureas, bolus insulin, and mixed insulin

Immunomodulation aims to restore normal immune balance by adjusting specific pathways without broadly weakening the immune system

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Physiol Behav 257:113967 Masaki T et al (2022) Glucagon-like peptide-1 receptor agonist semaglutide improves eating behavior and glycemic control in japanese obese type 2 diabetic patients