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A reasonable titration schedule might look like this: Week 1: 200mcg once daily Week 2: 300mcg once daily Week 3 onward: 300-500mcg based on response and tolerance Optimizing injection technique Poor injection technique contributes to injection site reactions and potentially to other effects like nausea from anxiety around the process

Complete medical history is required

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Furthermore, no studies exist investigating whether there is an over-representation of patients with Gilberts syndrome in those who develop toxicity following paracetamol overdose