In 2010, the New Zealand government funded a large grant to investigate the appetite suppressive effects of bitter plant compounds as a potential treatment option for weight management
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Nature Medicine, 30 (7), 2049-2057
This makes melanogenesis a potential source of ROS in pigmented cells, which in turn subjects melanocytes to high levels of oxidative stress
Mnatsakanyan, H., Serra, R
Renewal rules: how long approvals last The initial weight-loss approval runs 8 months