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However, p21 activates Rb to produce a bioactive secretome that places stressed cells under immunosurveillance

Expensive ($500-$2,000 per scan) limiting serial monitoring

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He also hypothesized that senolytic drugs can selectively eliminate senescent cells from patients with SLE and rejuvenate these tissues, improve organ function, and promote disease dormancy

it cannot establish superiority, because differences in population, comparator, endpoint, dose, and trial length confound any direct read