Mechanistically, GLP1RAs improve cardiac function by enhancing contractility and reducing myocardial injury 14,15,16 , exert vasodilatory and endothelial-protective effects, and display anti-inflammatory and anti-fibrotic actions that may limit adverse remodeling in heart failure (HF) 17
With prolonged use, the pituitary's baseline GH production decreases a well-documented endocrinological effect
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Statistics and reproducibility To exclude any sex-specific effects of GLP1R SNAP/SNAP knock-in, male and female animals were considered separately for metabolic phenotyping experiments
doi: 10.1096/fj.202100909RR 156 HeerspinkHJLPercoPMulderSLeiererJHansenMKHeinzelAet al
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