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Developed by the Danish pharmaceutical company Novo Nordisk, Saxenda was approved by the FDA in December 2014 for the treatment of chronic weight management, combined with a reduced-calorie diet and physical activity

Early lab studies found increases in beneficial gut bacteria such as Bifidobacterium , Faecalibacterium , and Akkermansia , plus higher short chain fatty acid production, which supports a healthy gut environment

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Inflammation and resolution in obesity

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13 Overall, neurohormonal mechanisms may contribute BP lowering effects, particularly in patients with heightened sympathetic tone, but their clinical relevance is less established than renal or vascular pathways