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The numbing effect lasts about 60 to 90 seconds, which is more than enough time to complete the injection

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ablation of the nausea-mediating AP, but not NTS, GLP-1R + neurons eliminates the conditioned taste avoidance response to semaglutide in rodents ( In summary, long-acting GLP-1R agonists primarily reach the circumventricular organs of the hindbrain and food-intake controlling centers of the hypothalamus