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Stopping semaglutide does not cause withdrawal symptoms, but you may notice some effects as your hormones change and your body adjusts, such as: an increase in appetite an increase in blood sugar levels not feeling as full as before All of these can cause weight regain when you stop semaglutide

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To evaluate changes in hepatic synthetic function and the development of hepatic decompensation, serial monitoring of Child-Turcotte-Pugh (CTP) score, model for end-stage liver disease (MELD) score, and new onset or worsening of liver-related events such as ascites, variceal bleeding, hepatic encephalopathy and HCC are needed