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The study found men who had low testosterone and Type 2 diabetes were six times more likely to have increased thickness of the carotid artery and endothelium dysfunction compared to men with normal serum testosterone levels

Am J Physiol Renal Physiol

Ciavardelli et al., 2016

Acute exposure of endothelial cells to hyperglycemic conditions increases acetylation of p53 and expression of p21, suggesting that O-GlcNAcylation leads to increased transcription of p53 target genes (Zhang et al., 2015)

In addition, FG strains are typically characterised by higher feed intake 28 , as was also observed in the current study (Table 1) and lower locomotor activity 16 , which may result in higher metabolisable energy availability

This approach allows localized delivery with minimal systemic exposure