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In people with type 2 diabetes, obesity, or metabolic conditions, the natural GLP-1 response may be impaired

(Handbook of clinical neurology)

Alternatively, agents from different classessuch as SGLT-2 inhibitors or DPP-4 inhibitorscould be discussed if glycaemic targets allow

However, interpreting individual results requires caution

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Retinopathy complications were defined as a composite of vitreous hemorrhage, onset of diabetes-related blindness, and a need for treatment with intravitreal injection or retinal photocoagulation, all serious clinical events