Berberine appears to increase GLP-1 by: Activating bitter taste receptors (TAS2Rs) that trigger the PLC (phospholipase C) signaling pathway in L-cells, which secrete GLP-1 Feeding beneficial bacteria in the gut that then produce short-chain fatty acids (SCFAs), which stimulate L-cells to secrete GLP-1 Gut microbiome health Berberine influences the gut microbiome, Agha-Khan says
doi: 10.1371/journal.pone.0079316 121 MirandaERDeyCS
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Serban C, Sahebkar A, Ursoniu S, Andrica F, Banach M