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Another uncertainty is that the underlying science is still in flux and debate rages among academic researchers over many details of how caloric restriction works

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Sin embargo, entre los pacientes que experimentaron al menos una exacerbacin, los grupos fueron similares respecto al nmero medio de eventos posteriores durante 12 meses (1,83 frente a 2,02)

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However, the weight loss effects observed in patients taking GLP-1 agonists for diabetes have led to an increase in off-label prescribing for obesity and weight management in individuals without diabetes