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These medications have also gained attention for their effectiveness in managing obesity, although coverage for weight loss remains limited under Medicare and Medicaid today

Safety and limitations SGLT2 inhibitors are generally well tolerated but are associated with an increased risk of genital infections [103,104] and, rarely, euglycemic diabetic ketoacidosis [105-107]

These results, however, must be taken into careful consideration, mainly because of a small number of analyzed clinical studies and high between-study heterogeneity [120]

Liraglutide is approved in Europe for patients with T2DM and mild or moderate kidney damage, but is currently not recommended or should be used with caution in patients with severe renal impairment (130)

Glucagon is essential for adaptive thermogenesis in brown adipose tissue

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death