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FDA must evaluate the advisory record and choose an agency action

Oxidative stress has been implicated in diseases such as cancer, arthritis, nonalcoholic fatty liver disease and diabetes

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Why that matters: cortisol and GLP-1 effectiveness are inversely linked, and perimenopausal estrogen decline dysregulates the HPA axis, raising baseline cortisol and driving hormonal belly fat redistribution that keeps women stuck at a normal BMI with real metabolic dysfunction