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Novo Nordisk's Saxenda (liraglutide): Saxenda, an earlier GLP-1 agonist, has a more established market presence but generally shows lower efficacy for weight loss compared to newer agents like Wegovy and Zepbound

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They found a fragment in her stifle

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The side effect profile, which includes significant nausea, GI disturbance, and muscle mass loss alongside fat loss, is the tradeoff

Semaglutide is not: it is a peptide eliminated by proteolytic cleavage of the peptide backbone and beta-oxidation of the fatty acid side chain, so the two do not share a hepatic CYP450 pathway