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Vinken et al

PMID: 24792335

In contrast, if metabolically competent human HepaRG cells [142] or primary human hepatocytes [46] were treated with 20 mM APAP for 24 h, there was 8090% GSH depletion, a ten-fold higher protein adducts formation, 7090% reduction of the mitochondrial membrane potential and 610-fold increase in LDH or ALT release

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One study found that people taking opiates (some of which contain acetaminophen) were 95 percent more likely to be obese and 63 percent more likely to have hypertension