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F1000Res 9 , 325

Borrelli, K

These medicines have become increasingly important in the management of type 2 diabetes and, more recently, obesity

In the case of the IP 3 R the ligand is inositol-1,4,5-trisphosphate

Although some of these controversies are clearly based on methodological problems and plain misinterpretation of the data, more recent studies demonstrate that multiple signaling mechanisms dependent on the experimental conditions in animals or specific circumstances in patients, can lead to different modes of APAP-induced cell death, which is the topic of this critical review, which is based on our extensive experience with this topic and the pertinent literature

doi:10.2337/dc18-0078