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LrB inhibits Ca 2+ influx and IL-2 secretion in Jurkat T-cells by inhibiting the KV1.3 and stromal interaction molecule 1 (STIM1)/Orai1 pathways, which can induce immunosuppressive effects (288)

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In this study (62), we designed an iron-based metal-organic framework (MIL-101) loaded with riboflavin nanoparticles for the treatment of bacterial keratitis through the photothermal synergistic dual mechanism of iron-death and immunomodulation: MIL-101 produces a mild thermal effect and releases Fe 3+ , which induces the ROS flare and bacterial lipid peroxidation through the Fenton reaction, triggering an iron-death-like bacterial effect