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An unusual association of three autoimmune disorders: celiac disease, systemic lupus erythematosus and Hashimotos thyroiditis

Copper can also oxidize Tau, forming intramolecular disulfide bridges via binding to the C291 and C322 on the R2 and R3 sequences, promoting both Tau phosphorylation and aggregation and also being detected in NFTs (Zubi et al., 2020)

H., & Hahm, K

It also decreases in the body as we age

Specifically, the hGH protein in this study was isolated from cadavers (not made recombinantly) and so the observed impact on immunogenicity may differ from the modern products available today