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As different APOE genotypes are shown to have different energy substrate preferences it is not surprising that L-carnitine administration affected levels of these FAO metabolites differently by genotype ( Several sex effects were also observed throughout these studies, where despite higher levels of total plasma acylcarnitines in females compared to males, in aging females, there was a significant decrease in total acylcarnitines which was not seen in aging males, indicating that aging may impact female peripheral lipid bioenergetics more than males

Regulatory pathways and drugs associated with ferroptosis in tumors