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Chalcones exhibit a wide range of biological activities, including anti-inflammatory, antioxidant, antimicrobial, and anticancer effects, largely through the modulation of signaling pathways such as nuclear factor kappa B (NF-B), phosphoinositide 3-kinase/protein kinase B (PI3K/Akt), and cyclooxygenase (COX) enzymes (Ugwu et al., 2016)

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