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Semaglutide works by slowing gastric emptying and signaling fullness to your brainbut this metabolic shift sometimes triggers temporary fatigue

Direct Drug Effect: While less understood, the direct pharmacological action of Ozempic on GLP-1 receptors in the central nervous system may also contribute to feelings of fatigue

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Treatment with GLP-1RAs reduces expression of -smooth muscle actin (-SMA) and collagen type I in HSCs, thereby attenuating fibrogenesis (18, 30)

POCUS or formal gastric ultrasound provides a noninvasive means to evaluate for residual solids or large fluid volumes