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While SURPASS-4 was not powered to evaluate differences in MACE-4 incidence between tirzepatide treatment groups and glargine, it was designed to fulfill the MACE-4 non-inferiority analysis requested by regulatory authorities to evaluate the cardiovascular safety of new glucose lowering medications

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The primary outcomes assessed included lipid profiles, insulin resistance, anthropometric measurements, leptin, serum glucose levels, blood pressure, and inflammatory markers

The one who doesn't ends up troubleshooting inconsistent results that were baked into the administration method from day one