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Every persistent or changing dark patch in the mouth deserves a careful look, most will turn out to be one of the benign differentials above, but in the rare case where it is melanoma, an early diagnosis can make a real difference to long-term outcome

Induction of c-Jun requires activation of c-Jun N-terminal kinase (JNK) through the phosphorylation on its Serine 63 and 73 residues

Role of non-invasive ventilation (NIV) in managing acute exacerbations of chronic obstructive pulmonary disease (COPD): a systematic review

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Patients should be advised to maintain adequate hydration, particularly if experiencing persistent vomiting or diarrhoea, and clinicians should consider monitoring renal function if severe gastrointestinal symptoms occur