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The AUAs 2020 guidelines underscore the need to consider comorbid conditions in hypogonadism treatment [4], and the EAU guidelines (2021) highlight the potential of pharmacologic agents to influence androgen levels indirectly [13]

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368 Since GLP-1R is expressed in thyroid C cells and GLP-1 directly stimulates the secretion of calcitonin, which is a potent inhibitor of bone resorption in osteoclasts, GLP-1 may contribute to the nutrient-mediated reduction in bone resorption

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