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doi: 10.1146/annurev-biochem-061516-045037 6

Hypnotics (benzodiazepines, z-drugs) force sleep by depressing the central nervous system and suppressing deep sleep phases

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Translation limit Animal and cell findings may not predict human outcomes because metabolism, exposure, receptor expression, administration route, and disease context differ

Muscle Tone and Firmness IGF-1 LR3 supports subtle increases in muscle tone, particularly in the glutes, shoulders, and legs without significant weight gain or bloating

Practice stress management techniques such as meditation, yoga, or deep breathing exercises to reduce stress and improve mental health