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The FDA ended shortage-related compounding in 2025 and, on April 30, 2026, proposed keeping tirzepatide off the 503B bulks list permanently

In this article, "GLP-1 patch" refers to a marketing label used onlinenot an FDA-recognized class of GLP-1 medication

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Kooij, Derek IJsbrand Koster, Emma Eeltink, Mieneke Luijendijk, Lisa Drost, Fabien Ducrocq, Roger A.H

Yet it also brings challenges in access, regulation, and trust

Notably, LEO activates the METTL3/AKT1S1 axis to induce autophagy, ameliorating macrophage lipid accumulation and suppressing atherosclerotic plaque formation (Yu et al., 2024)