This rebound effect occurs because the amylin receptor system, having adapted to sustained agonism, temporarily overcompensates when that stimulation is removed
Molecular pathogenesis of Wilson and Menkes disease: correlation of mutations with molecular defects and disease phenotypes
Effects of faecal microbiota transplantation on the small intestinal mucosa in systemic sclerosis
Several studies have shown that mega doses of the vitamin can lead to outbreaks of acne and rosacea which is a skin condition that causes redness and pus-filled bumps on the face
(Clin Transl Med, 2021) in 24 older adults (aged 61-80) found that supplementation with GlyNAC (glycine 100 mg/kg/day + NAC 100 mg/kg/day, approximately 7 g each for a 70 kg person) for 16 weeks corrected glutathione deficiency and improved multiple hallmarks of aging including oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, body composition, exercise capacity, and cognition [10]
And, in terms of nutrition, theres evidence that eating a high-fat, high-sugar diet can interfere with your cellular NAD levels and, in turn, mitochondrial function