tirzepatide phase 3 Once-weekly versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, trial The SURMOUNT-MAINTAIN Phase 3b trial

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LC improves CC in mice, in part through the carnitine palmitoyltransferase-associated PPAR-signaling pathway

doi: 10.2141/jpsa.0170132, 144

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A massive upregulation of PPAR was observed during ageing in ACOX deficient mice, suggesting ACOX substrates as endogenous activators of PPAR [109]

So far, deaths that have occurred during retatrutide trials have been assessed and found to be unrelated to treatment