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10.14336/AD.2022.0325 157 YuanY.ZhaoG.ZhaoY
NG136 Weinstock RS, Trief PM, Burke B, etal
Fiber supplements bulk up stool and require adequate water to work, while stool softeners like docusate soften existing stool to ease passage
To date, observational studies investigating the cardiovascular effectiveness of the combination have either been underpowered or had important methodological limitations, such as immortal time bias.1215181920 Importantly, none compared the combination with either drug class alone or investigated serious renal events, which are clinically relevant outcomes in this patient population.1215181920 The primary objective of this study was to determine whether the combined use of GLP-1 receptor agonists and SGLT-2 inhibitors is associated with a decreased risk of two co-primary outcomes, major adverse cardiovascular events and serious renal events, compared with the use of either drug class alone among patients with type 2 diabetes
The use of a single antioxidant compound in our study is a limitation, but previous research indicated that substituting NAC with other antioxidants can equally prevent behavioral deficits in neurodevelopmental model of schizophrenia [11]