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These techniques have become even more sensitive and reliable with lower detection limits in the last few years

It carries a boxed warning for increased suicidality, and is contraindicated in patients with uncontrolled hypertension or seizure disorder, and in those who are receiving long-term opioid therapy

Mol Biol Rep 45(6):19571966

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Rheumatology (Oxford) 62 (2), 905913