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Common starting protocols suggest 5mg twice weekly

Multivariate Hazard ratio (HR) was calculated with 95% confidence interval using multivariate Cox proportional hazards regression after adjustment for age, pT (Tumor size), pN (Regional lymph nodes), ER (Estrogen receptor), HER2 (Erb-B2 Receptor Tyrosine Kinase 2/HER2), tumor grade, patient age at diagnosis

Lastly, semaglutide downregulated several known regulators of pathologic hypertrophy (including Nppa, Ankrd23, Myh7, Gja5, Calm1), providing molecular insight into the antihypertrophic action of these drugs in HFpEF ( Figure 1C )

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