URL: Russell-Aulet M, Dimaraki EV, Jaffe CA, DeMott-Friberg R, Barkan AL
GLP-1R, when activated, initiates downstream signaling effects that lead to an overall decrease in blood glucose levels, including potentiation of insulin secretion, reduced glucagon secretion, and weight loss via satiety induction that results in increased insulin sensitivity (2)
They also intensify dietary restriction and restraint and exacerbate symptoms associated with starvation (e.g., irritability, preoccupation with food, fatigue, and social indifference), reinforcing the primary maintaining mechanisms of this eating disorder
Laboratory investigation
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