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Similar to GPx, catalase converts hydrogen peroxide into water and oxygen, thus preventing the buildup of hydrogen peroxide and inhibiting the formation of highly reactive hydroxyl radicals (OH) via the Fenton reaction (101, 102)

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worldobesity.org (2025)

This impairment mainly involves the System Xc /GSH/ GPX4 axis and nuclear factor erythroid 2-related factor 2 ( NRF2) -dependent transcriptional network ( System Xc ( SLC7A11 / SLC3A2 ) takes up cysteine to synthesize GSH( GPX4 to reduce phospholipid hydroperoxides ( activity leads to GSH consumption ( NRF2 plays a central role in maintaining cellular redox balance and limiting ferroptosis

This helps the body keep healthy levels of muscle mass, bone density, and good body composition as you age

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